ETaC: Pharmacochemistry - cancer epigenetic regulation unit

CNRS - Centre Pierre Fabre Laboratories - Research & Development Led by Paola B. Arimondo, USR 3388, Pierre Fabre Centre for Research & Development , secdir@etac.cnrs.fr 00 33 5 34 50 62 07

In brief

DNA epigenetic modifications: an interesting approach in therapy

Epigenetics or how to regulate access to genetic information: a new avenue in research against cancer

In the cell, a nucleus. In this nucleus, the DNA sequence (deoxyribonucleic acid), carrier of all the information it needs to synthesize its components and actors.

A same individual has in each cell the same genetic heritage and thus the same DNA sequence. Depending upon their role, some cells will use only a part of the information.

For example, a liver cell uses some of this information and the brain another. The so-called "epigenetic" changes are involved in this regulation, that is to say in the fact that this part will be read or not.

The epigenetic especially refers to DNA chemical modifications surrounding DNA, which are reversible and transmitted but which do not affect the sequence of the DNA and therefore the information of the cell.

 

Testimony

« These epigenetic changes are involved in all biological processes, even in diseases such as cancer. Since they are reversible, they can become interesting approaches in therapy. In some cases the information needed by the cell is present, you just have to make it available."
Paola B. Arimondo, USR 3388 Research Director, Pierre Fabre Centre for Research & Development. »

Paola B. Arimondo, USR 3388 Research Director, Pierre Fabre Centre for Research & Development